Protein isolated from Drosophila nervous system that is a member of the immunoglobulin superfamily. It contains 6 immunoglobulin-like domains and 5 fibronectin type III domains and has strong sequence homology to mouse NCAM and L1. Two different forms of neuroglian arise by differential splicing. These have identical extracellular domains but differ in the size of the cytoplasmic domains: the long form is restricted to neurons in central and peripheral nervous systems of embryos and larvae.

Dictionary of molecular biology. 2004.

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  • fasciclins — Cell adhesion molecules of the immunoglobulin superfamily found in the central nervous system of insects. Involved with fasciculation of axons and probably in pathfinding during morphogenesis of the nervous system. The sequence of fasciclin II… …   Dictionary of molecular biology

  • L1 — (= NgCAM) Neural adhesion molecule with 6 immunoglobulin type C2 domains and fibronectin type III repeats, making it another member of the immunoglobulin superfamily with binding domains similar to fibronectin. The purified molecule, immobilizd… …   Dictionary of molecular biology

  • NCAM — (= neural cell adhesion molecule) One of the first of the CAMs to be isolated from chick brain. Part of the immunoglobulin superfamily as is NgCAM (neural glial CAM). Initially defined by adhesion blocking antiserum. Thought to be important in… …   Dictionary of molecular biology

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